Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors
DC Field | Value | Language |
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dc.contributor.author | Lee, Soo Yeon | - |
dc.contributor.author | Hanseul Kweon | - |
dc.contributor.author | Kang, Hyojin | - |
dc.contributor.author | Eunjoon Kim | - |
dc.date.accessioned | 2023-01-26T02:36:35Z | - |
dc.date.available | 2023-01-26T02:36:35Z | - |
dc.date.created | 2022-11-29 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1662-5099 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/12626 | - |
dc.description.abstract | Autism spectrum disorders (ASD) are similar to 4-times more common in males than females, and CHD8 (a chromatin remodeler)-related ASD shows a strong male bias (similar to 4:1), although the underlying mechanism remains unclear. Chd8-mutant mice with a C-terminal protein-truncating mutation (N2373K) display male-preponderant behavioral deficits as juveniles and adults, although whether this also applies to other Chd8 mutations remains unknown. In addition, it remains unclear whether sexually dimorphic phenotypes in Chd8-mutant mice are differentially observed in males and females across different ages. We here generated new Chd8-mutant (knock-in) mice carrying a patient-derived mutation causing an N-terminal and stronger protein truncation (Chd8(+/S62X) mice) and characterized the mice by behavioral analyses. Juvenile Chd8(+/S62X) mice displayed male-preponderant autistic-like behaviors; hypoactivity and enhanced mother-seeking/attachment behavior in mates but not in females. Adult male and female Chd8(+/S62X) mice showed largely similar deficits in repetitive and anxiety-like behavioral domains. Therefore, the CHD8-S62X mutation induces ASD-like behaviors in juvenile male mice and adult male and female mice, pointing to an age-differential sexual dimorphism and also distinct sexual dimorphisms in different Chd8 mutations (N2373K and S62X). | - |
dc.language | 영어 | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000880911200001 | - |
dc.identifier.scopusid | 2-s2.0-85141388342 | - |
dc.identifier.rimsid | 79308 | - |
dc.contributor.affiliatedAuthor | Hanseul Kweon | - |
dc.contributor.affiliatedAuthor | Eunjoon Kim | - |
dc.identifier.doi | 10.3389/fnmol.2022.1022306 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN MOLECULAR NEUROSCIENCE, v.15 | - |
dc.relation.isPartOf | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.citation.title | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | CHD8 | - |
dc.subject.keywordPlus | AUTISM | - |
dc.subject.keywordPlus | CONNECTIVITY | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordAuthor | autism spectrum disorders | - |
dc.subject.keywordAuthor | CHD8 | - |
dc.subject.keywordAuthor | mouse model of ASD | - |
dc.subject.keywordAuthor | chromatin remodeling | - |
dc.subject.keywordAuthor | sexual dimorphism | - |
dc.subject.keywordAuthor | age dependence | - |