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Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics

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Title
Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics
Author(s)
Manuel Valero; Ipshita Zutshi; Euisik Yoon; György Buzsáki
Publication Date
2022-02
Journal
Science, v.375, no.6580, pp.570 - 574
Publisher
American Association for the Advancement of Science
Abstract
© 2022 American Association for the Advancement of Science. All rights reserved.Understanding how excitatory (E) and inhibitory (I) inputs are integrated by neurons requires monitoring their subthreshold behavior. We probed the subthreshold dynamics using optogenetic depolarizing pulses in hippocampal neuronal assemblies in freely moving mice. Excitability decreased during sharpwave ripples coupled with increased I. In contrast to this "negative gain," optogenetic probing showed increased within-field excitability in place cells by weakening I and unmasked stable place fields in initially non-place cells. Neuronal assemblies active during sharp-wave ripples in the home cage predicted spatial overlap and sequences of place fields of both place cells and unmasked preexisting place fields of non-place cells during track running. Thus, indirect probing of subthreshold dynamics in neuronal populations permits the disclosing of preexisting assemblies and modes of neuronal operations.
URI
https://pr.ibs.re.kr/handle/8788114/12057
DOI
10.1126/science.abm1891
ISSN
0036-8075
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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