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시냅스뇌질환연구단
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Turnover of fear engram cells by repeated experience

DC Field Value Language
dc.contributor.authorCho, Hye-Yeon-
dc.contributor.authorWangyong Shin-
dc.contributor.authorLee, Han-Sol-
dc.contributor.authorLee, Yeji-
dc.contributor.authorKim, Mujun-
dc.contributor.authorOh, Jung-Pyo-
dc.contributor.authorHan, Junho-
dc.contributor.authorJeong, Yire-
dc.contributor.authorSuh, Boin-
dc.contributor.authorEunjoon Kim-
dc.contributor.authorHan, Jin-Hee-
dc.date.accessioned2022-01-04T02:30:04Z-
dc.date.available2022-01-04T02:30:04Z-
dc.date.created2022-01-03-
dc.date.issued2021-12-20-
dc.identifier.issn0960-9822-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10973-
dc.description.abstractA sparse population of neurons active during a learning event has been identified as memory engram cells. However, cells that are recruited to support memory when experience is repeated have been scarcely explored. Evidence from previous studies provides contradictory views. To address these questions, we employed learning-dependent cell labeling in the lateral amygdala (LA) and applied electrophysiological recording, spine imaging, and optogenetic tools to the labeled neurons with or without retraining. We found that engram cells established from original fear learning became dispensable for memory retrieval specifically with relearning, and this correlated with a reduction of synaptic transmission and loss of dendritic spines in these neurons. Despite such decreased connectivity, direct activation of these neurons resulted in fear-memory recall. We further identified that repeated memory was encoded in neurons active during relearning. These results suggest a shift in neuronal ensembles encoding fear memory in the LA by relearning through disconnection of the existing engram neurons established from original experience.-
dc.language영어-
dc.publisherCELL PRESS-
dc.titleTurnover of fear engram cells by repeated experience-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000734334100005-
dc.identifier.scopusid2-s2.0-85121834710-
dc.identifier.rimsid77016-
dc.contributor.affiliatedAuthorWangyong Shin-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.identifier.doi10.1016/j.cub.2021.10.004-
dc.identifier.bibliographicCitationCURRENT BIOLOGY, v.31, no.24, pp.5450 - 5461-
dc.relation.isPartOfCURRENT BIOLOGY-
dc.citation.titleCURRENT BIOLOGY-
dc.citation.volume31-
dc.citation.number24-
dc.citation.startPage5450-
dc.citation.endPage5461-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaLife Sciences & Biomedicine - Other Topics-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusMEMORY CONSOLIDATION-
dc.subject.keywordPlusSYNAPSE ELIMINATION-
dc.subject.keywordPlusDENDRITIC SPINES-
dc.subject.keywordPlusHIPPOCAMPUS-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusTIME-
dc.subject.keywordPlusARC-
dc.subject.keywordPlusREPRESENTATIONS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusARC/ARG3.1-
dc.subject.keywordAuthorengram labeling-
dc.subject.keywordAuthorfear memory-
dc.subject.keywordAuthorlateral amygdala-
dc.subject.keywordAuthormemory engram-
dc.subject.keywordAuthormemory update-
dc.subject.keywordAuthoroptogenetics-
dc.subject.keywordAuthorrepeated experience-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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