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The complexity and regulation of repair of alkylation damage to nucleic acids

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Title
The complexity and regulation of repair of alkylation damage to nucleic acids
Author(s)
Tsao, Ning; Orlando D. Schärer; Mosammaparast, Nima
Publication Date
2021-03
Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, v.56, no.2, pp.125 - 136
Publisher
TAYLOR & FRANCIS LTD
Abstract
DNA damaging agents have been a cornerstone of cancer therapy for nearly a century. The discovery of many of these chemicals, particularly the alkylating agents, are deeply entwined with the development of poisonous materials originally intended for use in warfare. Over the last decades, their anti-proliferative effects have focused on the specific mechanisms by which they damage DNA, and the factors involved in the repair of such damage. Due to the variety of aberrant adducts created even for the simplest alkylating agents, numerous pathways of repair are engaged as a defense against this damage. More recent work has underscored the role of RNA damage in the cellular response to these agents, although the understanding of their role in relation to established DNA repair pathways is still in its infancy. In this review, we discuss the chemistry of alkylating agents, the numerous ways in which they damage nucleic acids, as well as the specific DNA and RNA repair pathways which are engaged to counter their effects.
URI
https://pr.ibs.re.kr/handle/8788114/10914
DOI
10.1080/10409238.2020.1869173
ISSN
1040-9238
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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