BROWSE

Related Scientist

RNA's photo.

RNA
RNA 연구단
more info

ITEM VIEW & DOWNLOAD

CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition

Cited 0 time in webofscience Cited 0 time in scopus
131 Viewed 0 Downloaded
Title
CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition
Author(s)
Yongsik Cho; Hyeon-Seop Kim; Donghyun Kang; Hyeonkyeong Kim; Narae Lee; Yun, Jihye; Kim, Yi-Jun; Min Lee, Kyoung; Kim, Jin-Hee; Kim, Hang-Rae; Hwang, Young-Il; Hyunchul Jo, Chris; Jin Hong Kim
Publication Date
2021-11
Journal
Science Advances, v.7, no.47
Publisher
American Association for the Advancement of Science
Abstract
© 2021 The Authors.Tendinopathy, the most common disorder affecting tendons, is characterized by chronic disorganization of the tendon matrix, which leads to tendon tear and rupture. The goal was to identify a rational molecular target whose blockade can serve as a potential therapeutic intervention for tendinopathy. We identified C1q/TNF-related protein-3 (CTRP3) as a markedly up-regulated cytokine in human and rodent tendinopathy. Overexpression of CTRP3 enhanced the progression of tendinopathy by accumulating cartilaginous proteoglycans and degenerating collagenous fibers in the mouse tendon, whereas CTRP3 knockdown suppressed the tendinopathy pathogenesis. Functional blockade of CTRP3 using a neutralizing antibody ameliorated overuse-induced tendinopathy of the Achilles and rotator cuff tendons. Mechanistically, CTRP3 elicited a transcriptomic pattern that stimulates abnormal differentiation of tendon stem/progenitor cells and ectopic chondrification as an effect linked to activation of Akt signaling. Collectively, we reveal an essential role for CTRP3 in tendinopathy and propose a potential therapeutic strategy for the treatment of tendinopathy.
URI
https://pr.ibs.re.kr/handle/8788114/10857
DOI
10.1126/sciadv.abg6069
ISSN
2375-2548
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse