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New Tool for Rapid and Accurate Detection of Interleukin-2 and Soluble Interleukin-2 Receptor α in Cancer Diagnosis Using a Bioresponsive Microgel and Multivalent Protein Binding

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dc.contributor.authorYang, Hae Min-
dc.contributor.authorYim, Bora-
dc.contributor.authorLee, Byung-Hyun-
dc.contributor.authorPark, Yongdoo-
dc.contributor.authorKim, Young Gyu-
dc.contributor.authorKim, Jongseong-
dc.contributor.authorDongwon Yoo-
dc.date.accessioned2021-12-08T05:30:01Z-
dc.date.available2021-12-08T05:30:01Z-
dc.date.created2021-08-26-
dc.date.issued2021-07-28-
dc.identifier.issn1944-8244-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10792-
dc.description.abstract© Interleukin-2 (IL-2) and its α receptor in soluble form (sIL-2Rα) are considered biomarkers for cancers and immune-related diseases. Enzyme-linked immunosorbent assay is the most common method used to evaluate biomarkers in clinical practice; it is precise but time-consuming and involves complicated procedures. Here, we have developed a rapid yet accurate modality for cancer diagnosis that enables on-site evaluation of cancer markers, that is, IL-2 and sIL-2Rα, without complicated pretreatment of cancer patient-derived blood samples. Surface plasmon resonance and bioresponsive microgels conjugated with IL-2 receptors, that is, IL-2Rβ and IL-2Rγ, were utilized to measure IL-2 and sIL-2Rα levels via multivalent protein binding (MPB) between the ligands and their receptors. Our results showed that this novel method enables us to perform cancer diagnosis with a 1000-fold dilution of serum in 10 min. The advantage of MPB-based cancer diagnosis originates from its great selectivity for a target molecule and tolerance to a myriad of nonspecific substances in serum, which allows on-site clinical evaluation. Importantly, our finding implies that MPB-based cancer diagnosis provides a new paradigm not only for improving cancer treatment but also for evaluating a target molecule in unpurified and complex solutions such as blood.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleNew Tool for Rapid and Accurate Detection of Interleukin-2 and Soluble Interleukin-2 Receptor α in Cancer Diagnosis Using a Bioresponsive Microgel and Multivalent Protein Binding-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000679917500004-
dc.identifier.scopusid2-s2.0-85111181392-
dc.identifier.rimsid76273-
dc.contributor.affiliatedAuthorDongwon Yoo-
dc.identifier.doi10.1021/acsami.1c04827-
dc.identifier.bibliographicCitationACS APPLIED MATERIALS & INTERFACES, v.13, no.29, pp.33782 - 33789-
dc.relation.isPartOfACS APPLIED MATERIALS & INTERFACES-
dc.citation.titleACS APPLIED MATERIALS & INTERFACES-
dc.citation.volume13-
dc.citation.number29-
dc.citation.startPage33782-
dc.citation.endPage33789-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusHYDROGEL-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusIL-2-
dc.subject.keywordPlusCHAIN-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusALPHA-
dc.subject.keywordPlusCELLS-
dc.subject.keywordAuthorhydrogel-
dc.subject.keywordAuthormultivalent protein binding-
dc.subject.keywordAuthorlabel-free-
dc.subject.keywordAuthorrapid detection-
dc.subject.keywordAuthorcancer diagnosis-
dc.subject.keywordAuthorbiosensor-
dc.subject.keywordAuthorsurface plasmon resonance-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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