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Shin, Wangyong
시냅스 뇌질환 연구단
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SALM4 negatively regulates NMDA receptor function and fear memory consolidation

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dc.contributor.authorEunkyung Lie-
dc.contributor.authorYeo, Yeji-
dc.contributor.authorLee, Eun-Jae-
dc.contributor.authorWangyong Shin-
dc.contributor.authorKyungdeok Kim-
dc.contributor.authorHan, Kyung Ah-
dc.contributor.authorYang, Esther-
dc.contributor.authorChoi, Tae-Yong-
dc.contributor.authorMihyun Bae-
dc.contributor.authorSuho Lee-
dc.contributor.authorUm, Seung Min-
dc.contributor.authorChoi, Se-Young-
dc.contributor.authorKim, Hyun-
dc.contributor.authorKo, Jaewon-
dc.contributor.authorEunjoon Kim-
dc.date.accessioned2021-11-09T07:50:05Z-
dc.date.available2021-11-09T07:50:05Z-
dc.date.created2021-11-01-
dc.date.issued2021-09-29-
dc.identifier.issn2399-3642-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10618-
dc.description.abstract© 2021, The Author(s).Many synaptic adhesion molecules positively regulate synapse development and function, but relatively little is known about negative regulation. SALM4/Lrfn3 (synaptic adhesion-like molecule 4/leucine rich repeat and fibronectin type III domain containing 3) inhibits synapse development by suppressing other SALM family proteins, but whether SALM4 also inhibits synaptic function and specific behaviors remains unclear. Here we show that SALM4-knockout (Lrfn3−/−) male mice display enhanced contextual fear memory consolidation (7-day post-training) but not acquisition or 1-day retention, and exhibit normal cued fear, spatial, and object-recognition memory. The Lrfn3−/− hippocampus show increased currents of GluN2B-containing N-methyl-d-aspartate (NMDA) receptors (GluN2B-NMDARs), but not α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors (AMPARs), which requires the presynaptic receptor tyrosine phosphatase PTPσ. Chronic treatment of Lrfn3−/− mice with fluoxetine, a selective serotonin reuptake inhibitor used to treat excessive fear memory that directly inhibits GluN2B-NMDARs, normalizes NMDAR function and contextual fear memory consolidation in Lrfn3−/− mice, although the GluN2B-specific NMDAR antagonist ifenprodil was not sufficient to reverse the enhanced fear memory consolidation. These results suggest that SALM4 suppresses excessive GluN2B-NMDAR (not AMPAR) function and fear memory consolidation (not acquisition).-
dc.language영어-
dc.publisherNature Research-
dc.titleSALM4 negatively regulates NMDA receptor function and fear memory consolidation-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000701977100002-
dc.identifier.scopusid2-s2.0-85116320041-
dc.identifier.rimsid76580-
dc.contributor.affiliatedAuthorEunkyung Lie-
dc.contributor.affiliatedAuthorWangyong Shin-
dc.contributor.affiliatedAuthorKyungdeok Kim-
dc.contributor.affiliatedAuthorMihyun Bae-
dc.contributor.affiliatedAuthorSuho Lee-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.identifier.doi10.1038/s42003-021-02656-3-
dc.identifier.bibliographicCitationCommunications Biology, v.4, no.1-
dc.relation.isPartOfCommunications Biology-
dc.citation.titleCommunications Biology-
dc.citation.volume4-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaLife Sciences & Biomedicine - Other Topics-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryBiology-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusADHESION-LIKE MOLECULES-
dc.subject.keywordPlusLONG-TERM POTENTIATION-
dc.subject.keywordPlusPHOSPHORYLATION SITES-
dc.subject.keywordPlusSYNAPTIC PLASTICITY-
dc.subject.keywordPlusFAMILY-
dc.subject.keywordPlusFLUOXETINE-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusSUBUNIT-
dc.subject.keywordPlusNEUROLIGINS-
dc.subject.keywordPlusEXCITATION-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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