BROWSE

Related Scientist

Byung Gyu, Kim's photo.

Byung Gyu, Kim
유전체 항상성 연구단
more info

ITEM VIEW & DOWNLOAD

Agl9: A novel hepatoprotective peptide from the larvae of edible insects alleviates obesity-induced hepatic inflammation by regulating ampk/nrf2 signaling

DC Field Value Language
dc.contributor.authorFan, Meiqi-
dc.contributor.authorChoi, Young-Jin-
dc.contributor.authorTang, Yujiao-
dc.contributor.authorKim, Ji Hye-
dc.contributor.authorByung-gyu Kim-
dc.contributor.authorLee, Bokyung-
dc.contributor.authorBae, Sung Mun-
dc.contributor.authorKim, Eun-Kyung-
dc.date.accessioned2021-10-15T08:30:01Z-
dc.date.available2021-10-15T08:30:01Z-
dc.date.created2021-09-27-
dc.date.issued2021-09-
dc.identifier.issn2304-8158-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10418-
dc.description.abstract© 2021 by the authors. Licensee MDPI, Basel, Switzerland.In this study, we investigated the anti-obesity properties of the novel peptide Ala-Gly-Leu-Gln-Phe-Pro-Val-Gly-Arg (AGL9), isolated from the enzymatic hydrolysate of Allomyrina dichotoma larvae. To investigate the preventive effects of AGL9 against hepatic steatosis and its possible mechanisms of action, we established an nonalcoholic fatty liver disease (NAFLD) model by feeding C57BL/6 mice a high-fat diet. NAFLD mice were administered 100 mg/kg AGL9 and 60 mg/kg orlistat via gavage (10 mL/kg) for 5 weeks, followed by the collection of blood and liver tissues. We found that AGL9 normalized the levels of serum alanine aminotransferase, aspartate amino-transferase, triglyceride, total cholesterol, high-density lipoprotein, very low-density lipoprotein (LDL)/LDL, adiponectin, and leptin in these mice. Additionally, AGL9 activated the protein-level expression of 5′ AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation and the transcript-level expression of sterol regulatory element-binding protein-1c, fatty acid synthase, superoxide dismutase, glutathione peroxidase, glucocorticoid receptor, nuclear respiratory factor 2, tumor necrosis factor-α, interleukin-1β, interleukin-6, and monocyte chemoattractant protein-1 in hepatocytes. These results showed that AGL9 exhibited hepatoprotective effects by attenuating lipid deposition, oxidative stress, and inflammation via inhibition of AMPK/Nrf2 signaling, thereby reducing the production of hepatic proinflammatory mediators and indicating AGL9 as a potential therapeutic strategy for NAFLD.-
dc.language영어-
dc.publisherMDPI AG-
dc.titleAgl9: A novel hepatoprotective peptide from the larvae of edible insects alleviates obesity-induced hepatic inflammation by regulating ampk/nrf2 signaling-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000700654900001-
dc.identifier.scopusid2-s2.0-85113954752-
dc.identifier.rimsid76405-
dc.contributor.affiliatedAuthorByung-gyu Kim-
dc.identifier.doi10.3390/foods10091973-
dc.identifier.bibliographicCitationFoods, v.10, no.9-
dc.relation.isPartOfFoods-
dc.citation.titleFoods-
dc.citation.volume10-
dc.citation.number9-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaFood Science & Technology-
dc.relation.journalWebOfScienceCategoryFood Science & Technology-
dc.subject.keywordPlusFATTY LIVER-DISEASE-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusNAFLD-
dc.subject.keywordAuthorAGL9-
dc.subject.keywordAuthorHepatic lipid metabolism-
dc.subject.keywordAuthorHepatoprotective peptide-
dc.subject.keywordAuthorInflammation-
dc.subject.keywordAuthorNonalcoholic fatty liver disease-
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse