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면역 미생물 공생 연구단
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A blend of broadly-reactive and pathogen-selected V gamma 4 V delta 1 T cell receptors confer broad bacterial reactivity of resident memory gamma delta T cells

DC Field Value Language
dc.contributor.authorKhairallah, Camille-
dc.contributor.authorBettke, Julie A.-
dc.contributor.authorGorbatsevych, Oleksandr-
dc.contributor.authorQiu, Zhijuan-
dc.contributor.authorZhang, Yue-
dc.contributor.authorCho, Kyungjin-
dc.contributor.authorKim, Kwang Soon-
dc.contributor.authorChu, Timothy H.-
dc.contributor.authorImperato, Jessica N.-
dc.contributor.authorHatano, Shinya-
dc.contributor.authorRomanov, Galina-
dc.contributor.authorYoshikai, Yasunobo-
dc.contributor.authorPuddington, Lynn-
dc.contributor.authorSurh, Charles D.-
dc.contributor.authorBliska, James B.-
dc.contributor.authorvan der Velden, Adrianus W. M.-
dc.contributor.authorSheridan, Brian S.-
dc.date.accessioned2021-10-12T02:30:03Z-
dc.date.available2021-10-12T02:30:03Z-
dc.date.created2021-09-27-
dc.date.issued2021-01-
dc.identifier.issn1933-0219-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10399-
dc.description.abstractAlthough murine gamma delta T cells are largely considered innate immune cells, they have recently been reported to form long-lived memory populations. Much remains unknown about the biology and specificity of memory gamma delta T cells. Here, we interrogated intestinal memory V gamma 4 V delta 1 T cells generated after foodborne Listeria monocytogenes (Lm) infection to uncover an unanticipated complexity in the specificity of these cells. Deep TCR sequencing revealed that a subset of non-canonical V delta 1 clones are selected by Lm infection, consistent with antigen-specific clonal expansion. Ex vivo stimulations and in vivo heterologous challenge infections with diverse pathogenic bacteria revealed that Lm-elicited memory V gamma 4 V delta 1 T cells are broadly reactive. The V gamma 4 V delta 1 T cell recall response to Lm, Salmonella enterica serovar Typhimurium (STm) and Citrobacter rodentium was largely mediated by the gamma delta TCR as internalizing the gamma delta TCR prevented T cell expansion. Both broadly-reactive canonical and pathogen-selected non-canonical V delta 1 clones contributed to memory responses to Lm and STm. Interestingly, some non-canonical gamma delta T cell clones selected by Lm infection also responded after STm infection, suggesting some level of cross-reactivity. These findings underscore the promiscuous nature of memory gamma delta T cells and suggest that pathogen-elicited memory gamma delta T cells are potential targets for broad-spectrum anti-infective vaccines.-
dc.language영어-
dc.publisherSPRINGERNATURE-
dc.titleA blend of broadly-reactive and pathogen-selected V gamma 4 V delta 1 T cell receptors confer broad bacterial reactivity of resident memory gamma delta T cells-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000691757000001-
dc.identifier.scopusid2-s2.0-85113998035-
dc.identifier.rimsid76439-
dc.contributor.affiliatedAuthorSurh, Charles D.-
dc.identifier.doi10.1038/s41385-021-00447-x-
dc.identifier.bibliographicCitationMUCOSAL IMMUNOLOGY-
dc.relation.isPartOfMUCOSAL IMMUNOLOGY-
dc.citation.titleMUCOSAL IMMUNOLOGY-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.subject.keywordPlusLISTERIA-MONOCYTOGENES-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusINNATE-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusHOMEOSTASIS-
dc.subject.keywordPlusSKIN-
dc.subject.keywordPlusEXPANSION-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordPlusANTIGEN-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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