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Publication Date2022-02
A combination of direct reversion and nucleotide excision repair counters the mutagenic effects of DNA carboxymethylation
Aloisi, Claudia M.N.; Escher, Nora A.; Hyun Suk Kim, et al
DNA Repair, v.110
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Publication Date2023-03
A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair
van, den Heuvel D.; Mihyun Kim; Wondergem, A.P., et al
Proceedings of the National Academy of Sciences of the United States of America, v.120, no.11
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Publication Date2020-02
A key interaction with RPA orients XPA in NER complexes
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NUCLEIC ACIDS RESEARCH, v.48, no.4, pp.2173 - 2188
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Publication Date2022-04
Active DNA damage eviction by HLTF stimulates nucleotide excision repair
van Toorn, Marvin; Turkyilmaz, Yasemin; Han, Sueji, et al
Molecular Cell, v.82, no.7, pp.1343 - 1358.e8
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Publication Date2023-09
Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors
Minwoo Wie; Keon Woo Khim; Arnold S Groehler Iv, et al
NAR Cancer, v.5, no.3
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Publication Date2023-12
Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy
Slyskova, Jana; Muniesa-Vargas, Alba; Da Silva, Israel Tojal, et al
NAR Cancer, v.5, no.4
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Publication Date2023-05
Development of Comprehensive Ultraperformance Liquid Chromatography-High-Resolution Mass Spectrometry Assays to Quantitate Cisplatin-Induced DNA-DNA Cross-Links
Arnold S. Groehler; Asema Maratova; Nhat Mai Dao, et al
CHEMICAL RESEARCH IN TOXICOLOGY, v.36, no.6, pp.822 - 837
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Publication Date2017-05
Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair
Beagan, K; Armstrong, RL; Witsell, A, et al
PLOS GENETICS, v.13, no.5, pp.e1006813
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Publication Date2023-03
EEPD1 promotes repair of oxidatively-stressed replication forks
Jaiswal, Aruna S.; Hyun-Suk Kim; Orlando D. Schärer, et al
NAR Cancer, v.5, no.1
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Publication Date2020-12
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair
Susan E. Tsutakawa; Chi-Lin Tsai; Chunli Yan, et al
DNA REPAIR, v.96, pp.102972
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Publication Date2021-03-01
ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients
Apelt, Katja; White, Susan M.; Hyun Suk Kim, et al
Journal of Experimental Medicine, v.218, no.3, pp.1 - 25
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Publication Date2017-07
ERCC1-XPF endonuclease-positioned to cut
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EMBO JOURNAL, v.36, no.14, pp.1993 - 1995
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Publication Date2017-11
FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response
Elizabeth L. Thompson; Jung E. Yeo; Eun-A Lee, et al
NUCLEIC ACIDS RESEARCH, v.45, no.20, pp.11837 - 11857
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Publication Date2020-04
Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery
Maya Raghunandan; Jung Eun Yeo; Ryan Walter, et al
HUMAN MOLECULAR GENETICS, v.29, no.7, pp.1083 - 1095
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Publication Date2019-08
MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers
Srinivasan G.; Williamson E.A.; Kong K., et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.116, no.35, pp.17438 - 17443
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Publication Date2018-11
Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair
Hong Mu; Nicholas E. Geacintov; Suse Broyde, et al
DNA REPAIR, v.71, pp.33 - 42
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Publication Date2023-06
MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1
Jung-Min Oh; Kang, Yujin; Park, Jumi, et al
NUCLEIC ACIDS RESEARCH, v.51, no.11, pp.5584 - 5602
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Publication Date2021-07-19
New Synthetic Analogs of Nitrogen Mustard DNA Interstrand Cross-Links and Their Use to Study Lesion Bypass by DNA Polymerases
Young K. Cheun; Arnold S. Groehler; Orlando D. Schärer
CHEMICAL RESEARCH IN TOXICOLOGY, v.34, no.7, pp.1790 - 1799
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Publication Date2021-12
Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes
Apelt, Katja; Lans, Hannes; Orlando D. Schärer, et al
Cellular and Molecular Life Sciences, v.78, no.24, pp.7925 - 7942
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Publication Date2021-05
PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations
Alexander von Werdt; Laura Brandt; Orlando D. Scharer, et al
JCO Precision Oncology, v.5, pp.1639 - 1649
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Publication Date2022-11
Polycarcin V induces DNA damage response and enables the profiling of DNA-binding proteins
Yue, Zongwei; Wu, Fan; Guo, Fusheng, et al
NATIONAL SCIENCE REVIEW, v.9, no.11
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Publication Date2017-03
Preparation of Stable Nitrogen Mustard DNA Interstrand Cross-Link Analogs for Biochemical and Cell Biological Studies
Alejandra Castaño; Upasana Roy; Orlando D. Sch€arer
METHODS IN ENZYMOLOGY, v.591, pp.415 - 431
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Publication Date2020-03
Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation
Kook Son; Orlando D. Scha¨ rer
CELL, v.180, no.6, pp.1039 - 1041
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Publication Date2020-12
SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
Julie Rageul; Jennifer J. Park; Ping Ping Zeng, et al
NATURE COMMUNICATIONS, v.11, no.1, pp.5495
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Publication Date2017-10
Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway
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CELL REPORTS, v.21, no.5, pp.1375 - 1385
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Publication Date2019-09
Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B
Na Young Cheon; Hyun-Suk Kim; Jung-Eun Yeo, et al
NUCLEIC ACIDS RESEARCH, v.47, no.16, pp.8337 - 8347
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Publication Date2020-04
Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex
Jeong E.; Seong-Gyu Lee; Hyun-Suk Kim, et al
NUCLEIC ACIDS RESEARCH, v.48, no.6, pp.3328 - 3342
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Publication Date2018-04
Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease
Hyeonseok Jin; Upasana Roy; Gwangrog Lee, et al
JOURNAL OF BIOLOGICAL CHEMISTRY, v.293, no.17, pp.6482 - 6496
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Publication Date2022-07
Transcriptional Perturbations of 2,6-Diaminopurine and 2-Aminopurine
Tan, Ying; You, Changjun; Jiyeong Park, et al
ACS CHEMICAL BIOLOGY, v.17, no.7, pp.1672 - 1676
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Publication Date2022-08
Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair
Mihyun Kim; Hyun Suk Kim; D’Souza, Areetha, et al
Proceedings of the National Academy of Sciences of the United States of America, v.119, no.34
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Publication Date2022-08
XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
Blessing, Charlotte; Apelt, Katja; van den Heuvel, Diana, et al
NATURE COMMUNICATIONS, v.13, no.1
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Publication Date2023-01
ZNF212 promotes genomic integrity through direct interaction with TRAIP
Chung, Hee Jin; Lee, Joo Rak; Tae Moon Kim, et al
NUCLEIC ACIDS RESEARCH, v.51, no.2, pp.631 - 649